The National Israel Brain Repository: Characterizing those who sign and do not sign intent to autopsy

Background Collection of postmortem human brain and spinal cords for research is invaluable, especially in neurodegeneration, since clinicopathologic data may lead to better understanding their pathophysiology new therapeutic targets. The National Israel Brain Repository was established 2018 began recruiting donors from two large-scale community-based studies individuals at high dementia risk: older adults with type 2 diabetes (Israel Diabetes Cognitive Decline study-IDCD) middle-aged offspring AD patients (The Registry Alzheimer’s Prevention- IRAP).We compared sociodemographic, cardiovascular (CVRFs)and cognitive characteristics who agreed did not agree sign intent autopsy (ITA) Method In the IDCD, 750 active participants, we approached 636. Of them, 196 (31%) ITA.IRAP has 480 participants whom 395 were them 176 (45%) ITA. All are Maccabi Health Services, providing CVRF 1998. Using t-test groups on sociodemographic CVRFs. For which averages 36-months follow ups, mixed regression models adjusting age, sex education tested whether signing ITA predicted trajectories. IRAP, whose follow-ups have only recently begun, used linear regressions same covariates, functioning between those Result IRAP sample, signed differ any except HbA1c (Table 1). IDCD had higher education, creatinine, BMI motor function (hand grip 3-meter walk). Finally, a slower rate decline episodic memory (Estimate = 0.002, SE 0.001, p 0.05) Conclusion Our results suggest that risk willing donate brains science do or CVRFs wish be organ donors. contrast, due T2D more educated, suggesting selection bias towards health.Development strategies diminish this warranted.